What sort of conjectures and major open problems are the most important in algorithmic game theory (or game theory in general as it relates to CS)? For example, the resolution of NASH as being PPAD-complete would, I think, have been the biggest one up until it was resolved.
(Added: resolving PPAD's relation to P and NP is one good open problem, but others not so deeply entrenched in computational complexity would be nice too.)