the rule 110 initial condition constructions are extremely intricate even for simple computations and generally cannot be constructed by hand. one would generally start with a real/concrete TM [turing machine] built to compute your problem, ie the complete state table (TMs are of course alluded to in thousands of TCS papers but rarely actually built directly).
generally the papers build initial conditions using complex algorithmic conversions to tag systems. the cook paper cited by DE in comments above does improve the simulation time by a polynomial instead of exponential construction. in other words, theres more than one way to create suitable initial conditions. another recent construction with emphasis on regular languages by martinez et al can be found. the authors of the papers generally do not seem to release code they used to construct their paper results [scanning the two papers below], a legitimate complaint that could be made of much research papers in TCS which tend to give short shrift to experimental approaches even as they seem to focus on them.
so once you have the TM alphabet and state table one runs the conversion algorithms described but not really explicitly/manifestly implemented in the papers [because no code is given, only a prose description of the algorithm(s)] which take the TM alphabet and state table as input and then output a tag-system setup and 110 initial tape conditions that simulates the TM. my understanding is that in some cases, an infinite periodic starting "tape" pattern may be required.
in their papers they do not even seem to mention what coding languages they use for their simulations/experiments. they might release code if you contact them directly. therefore wolframs release/publishing of some mathematica code you mention above [nice but now rather dated based on later developments in the area] seems to be an exception in this area. therefore to actually independently construct concrete machines built using these techniques a researcher might have to reimplement the algorithms described in the papers.
footnote: the exact TM problem must be defined with some care because in your case, does a TM that simply erases and outputs 2 to its tape compute 1+1? you probably want a TM that computes $a+b$ and starts with input 1,1 on the tape.
 A concrete view of rule 110 computation by matthew cook
 Reproducing the cyclic tag system
developed by Matthew Cook with
Rule 110 using the phases fi_1 by Martinez et al
 Is "Experimental Complexity Theory" being used to solve open problems?