It is easy to show (by probabilistic argument) that there exist functions that require circuits of size $O(2^n/n)$. This, in turn, can be used to prove a non-deterministic hierarchy theorem showing (roughly) that if $2^n/n > T(n) \gg t(n)$ then there exist functions that can be computed by circuits of size $T$ but not by circuits of size $t$.
What is known if we are instead interested in approximating functions rather than computing them exactly? This question can be asked in many ways, but for concreteness let us say that $f \in approxSIZE(t)$ if there is a circuit family of size $t$ that (for each input length) computes $f$ correctly 3/4 of the time. What can be said about existence of hard functions here? What kind of hierarchy theorem is known? Does the answer change if we require the circuits to compute $f$ correctly $1-1/n$ of the time?
Note (added after Ryan Williams's answer): In fact, the answer to my first question follows from a simple modification of Shannon's lower bound, since a circuit on $n$ input bits can only $\epsilon$-approximate $\sum_{i=0}^{\epsilon \cdot 2^n} {2^n \choose i} < 2^{H(\epsilon) \cdot 2^n}$ functions, where $H$ denotes the binary entropy function. A hierarchy theorem should follow from this in the usual way.