Can every function $f : \{0,1\}^* \to \{0,1\}$ that is computable in time $t$ on a single-tape Turing machine using an alphabet of size $k = O(1)$ be computed in time $O(t)$ on a single-tape Turing machine using an alphabet of size $3$ (say, $0,1,$ and blank)?
(From comments below by the OP) Note the input is written using $0,1$, but the Turing machine using alphabet of size $k$ can overwrite the input symbols with symbols from the larger alphabet. I don't see how to encode symbols in the larger alphabet in the smaller alphabet without having to shift the input around which would cost time $n^2$.