If I'm not mistaken it is not known whether $E^{NP} \subseteq {\rm SIZE}(n)$ where $E^{NP}$ is the class of problems solvable by a TM which works in time $2^{O(n)}$ and is allowed to make queries of size $2^{O(n)}$ to an NP oracle, and ${\rm SIZE(n)}$ is the class of functions solvable by non-uniform circuits of size $O(n)$.
Since ${\rm NSPACE}[n]\subseteq E \subseteq E^{NP}$ the above observation implies that the question of whether ${\rm NSPACE}[n]\subseteq {\rm SIZE}[n]$ is open.
Questions:
- What is the smallest function $f(n)$ such that it is known unconditionally that ${\rm NSPACE}[f(n)]\nsubseteq {\rm SIZE}[n]$?
- What is the smallest class $\mathcal{C}$ containing $E^{NP}$ such that it is known unconditionally that $\mathcal{C}\nsubseteq SIZE[n]$?
- What is a good reference for relations between uniform and non-uniform circuit classes?